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JNCI Journal of the National Cancer Institute 2003 95(17):1262-1263; doi:10.1093/jnci/djg062
© 2003 by Oxford University Press
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© 2003 Oxford University Press

EDITORIAL

Bisphosphonates in Prostate Cancer: Where Are We and Where Should We Go?

Fred Saad

Correspondence to: Fred Saad, MD, Division of Urologic Oncology, University of Montreal Hospital Center, 1560 Sherbrooke East, Montreal, Quebec, Canada H2L 4M1 (e-mail: fred.saad.chum@ssss.gouv.qc.ca).

The first 10% of the full text of this article appears below.

Bone metastases are frequent occurrences in prostate cancer. The discovery that prostate cancer is a hormone-dependent cancer substantially altered strategies for treating this disease. Hormone therapy has since become the focus of much of the therapeutic improvement in the management of advanced prostate cancer. The use of hormone therapy prior to the appearance of metastases has resulted in improved survival in randomized studies and has led to the widespread use of early, as well as adjuvant, hormone therapy. One of the drawbacks of long-term hormone therapy has been reported in recent studies on the effects of androgen-deprivation therapy on bone metabolism. We now . . . [Full Text of this Article]


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