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JNCI Journal of the National Cancer Institute 2003 95(16):1190-1192; doi:10.1093/jnci/95.16.1190
© 2003 by Oxford University Press
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© 2003 Oxford University Press

NEWS

Fanconi Anemia Research Opens New Doors in Understanding of Cancer

Jeanne Erdmann

The first 150 words of the full text of this article appear below.

When oncologist Alan D’Andrea M.D., of the Dana-Farber Cancer Institute, Boston, began sorting through Fanconi anemia genes for connections to other cancer genes, he was heading down a well-trodden path in cancer biology. Although Fanconi anemia is uncommon, hereditary diseases that predispose people to early cancers or to rare cancers have helped scientists understand tumor suppressor genes such as p53 and the retinoblastoma (Rb) gene.


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  		The above pathway proposed by Alan D’Andrea, M.D., shows how seven Fanconi anemia proteins respond to DNA damage using homologous recombination, a signaling pathway common to other diseases marked by chromosome breakage, such as ataxia telangiectasia. (Reprinted from Curr Biol. 2003;13:R546 with permission from Elsevier.)

 
D’Andrea noticed a striking resemblance between breast tumor cells carrying BRCA mutations and the cells of his Fanconi patients. Cells from both conditions were sensitive to chromosome breakage.

Could there be a connection? Indeed there was. He and his colleagues . . . [Full Text of this Article]

A Rare Disease

A Common Repair Pathway

Fanconi-BRCA and Ovarian Cancer

Understanding the Cell Cycle


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