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JNCI Journal of the National Cancer Institute 2003 95(15):1105-1106; doi:10.1093/jnci/95.15.1105
© 2003 by Oxford University Press
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© 2003 Oxford University Press

NEWS

The Will Rogers Phenomenon: Roping the Effects of a New Cancer Staging System

Damaris Christensen

The first 10% of the full text of this article appears below.

At least in some cases, historical controls may become history, thanks to the recent changes in a national set of cancer staging guidelines. A large study has shown that using the new American Joint Committee on Cancer (AJCC) staging guidelines—in place as of January 2003—results in dramatic artifactual improvements in stage-specific survival among women with locally advanced breast cancer. Although unlikely to affect treatment decisions, the findings suggest that comparing the results of current clinical trials to historical controls may result in misleading benefits.

The problem has been dubbed the "Will Rogers phenomenon," because the situation resembles that of a classic Will Rogers quote, "When . . . [Full Text of this Article]

Changes to Staging System

Metastatic Disease

‘Falsely Downstaging’


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