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JNCI Journal of the National Cancer Institute 2003 95(12):844-846; doi:10.1093/jnci/95.12.844
© 2003 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 95, No. 12, 844-846, June 18, 2003
© 2003 Oxford University Press

NEWS

Of Cancer and Cholesterol: Studies Elucidate Anticancer Mechanisms of Statins

Vicki Brower

The first 10% of the full text of this article appears below.

Statins are drugs that reduce cholesterol in the management and prevention of cardiovascular disease. But according to a growing body of research gathered over the past decade, statins also have potential for use in cancer management.


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  		In 1999, Khandan Keyomarsi, Ph.D., and colleagues proposed that lovastatin induces the cyclin-dependent kinase inhibitors p21 and p27 in breast cancer cells by modulating the ubiquitin-proteasome pathway, independent of the HMG-CoA reductase enzyme. (Source: Proc Natl Acad Sci U S A 1999;96:7797–802.) (©1999 National Academy of Sciences, U.S.A. Reprinted with permission.)

 
Most recently, Khandan Keyomarsi, Ph.D., associate professor of experimental radiation oncology at the University of Texas M. D. Anderson Cancer Center in Houston, demonstrated that, in addition to lowering cholesterol by blocking the synthesis of a key enzyme, statins have an anticancer effect by acting through . . . [Full Text of this Article]


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