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JNCI Journal of the National Cancer Institute 2003 95(11):770-772; doi:10.1093/jnci/95.11.770
© 2003 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 95, No. 11, 770-772, June 4, 2003
© 2003 Oxford University Press

NEWS

Why it Hurts: Researchers Seek Mechanisms of Cancer Pain

Ken Garber

The first 150 words of the full text of this article appear below.

Pain is universal, but cancer pain is particularly vicious. "Cancer patients have a bond that surpasses a healthy person’s understanding," prostate cancer patient Cornelius Ryan, a prominent historian, wrote in his journal. "The presence of fear and the agony of pain are transmitted without words ... . My young friend [with lung cancer] wanted to die. [She] was being crucified by pain she could no longer endure. Now she is one more statistic."* The following year Ryan, in constant agony from bone metastases to his hips and legs, also died from his cancer.

While acknowledging the severity of cancer pain, doctors—until a few years ago—did not view it as fundamentally different, in terms of neurophysiology, from other kinds of pain. Cancer pain was thought to be caused by the growing tumor mass compressing or infiltrating soft tissue, pressing on peripheral nerves, and sometimes cutting off blood flow to defined areas . . . [Full Text of this Article]

Modeling Cancer Pain

From Bones to Brain

The New Painkillers


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