© 2003 by Oxford University Press
Journal of the National Cancer Institute, Vol. 95, No. 1, E1,
January 1, 2003
© 2003 Oxford University Press
PERSPECTIVES ON CLASSIC ARTICLES |
-Carotene and Lung Cancer: A Lesson for Future Chemoprevention Investigations?
Affiliation of author: Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Correspondence to: Peter Greenwald, M.D., Dr.P.H., Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, 6130 Executive Boulevard, Suite 2040, Bethesda, MD 20892-7309 (e-mail: greenwap@dcpc31.nci.nih.gov).
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INTRODUCTION |
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The search for chemoprevention agents to reduce the incidence and burden of cancer has become an increasingly important priority for medical researchers during the past two decades. Focusing on single nutrients, multiple dietary constituents, or complete diets has led researchers to a host of promising agents (1). Among these,
-carotene—an antioxidant that is present in many fruits and vegetables—has been the subject of some of the most intensive chemoprevention research on the basis of substantial evidence from epidemiologic studies that this nutrient has potential to reduce the risk of cancer at various sites, including lung and stomach and possibly esophagus, colorectum, breast, prostate, and cervix (2,3). -carotene is one of the most commonly used dietary supplements and has been heavily marketed to consumers for protection against cancer, cataracts, and heart disease. The U.S. Food and Drug Administration (FDA) designates -carotene as "Generally |
Summary of the ATBC Study and CARET |
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Issues Related to the ATBC Study and CARET |
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Importance of the ATBC Study and CARET |
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Implications for the Future |
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Correspondence about this Article
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CORRESPONDENCE: Re: -Carotene and Lung Cancer: A Lesson for Future Chemoprevention Investigations?
- Daniel O. Stram and Anna H. Wu
J Natl Cancer Inst 2003 95: 4E.[Extract] [Full Text]
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