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JNCI Journal of the National Cancer Institute 2003 95(1):6-7; doi:10.1093/jnci/95.1.6
© 2003 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 95, No. 1, 6-7, January 1, 2003
© 2003 Oxford University Press

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In Clinical Trials and In the Clinic, What Is the Placebo’s Effect?

Linda Wang

The first 10% of the full text of this article appears below.

For certain nonmalignant diseases, just the act of giving patients what they believe to be a drug can lead to improvements in their symptoms. This so-called placebo effect has been shown to relieve postoperative pain and to reduce anxiety and depression.

In cancer, some studies have found that patients taking a placebo sometimes experience a reduction in pain and other cancer-related symptoms. However, the question remains whether there is a true "placebo effect" in cancer patients, either for the symptoms of cancer or for the disease itself.

In a review article in this issue of the Journal (see p. 19), Giséle Chvetzoff, M.D., of the Centre Léon Bérard in Lyon, France, and Ian F. Tannock, M.D., Ph.D., of the Princess Margaret Hospital in Toronto, found that placebos were sometimes associated with improvement in symptoms such as pain and appetite but rarely associated with positive . . . [Full Text of this Article]

Clinical Trials

Clinical Use


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