Biological Significance of Interventions That Change Breast Density

doi:10.1093/jnci/95.1.4

JNCI Journal of the National Cancer Institute 2003 95(1):4-5; doi:10.1093/jnci/95.1.4
© 2003 by Oxford University Press

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Journal of the National Cancer Institute, Vol. 95, No. 1, 4-5, January 1, 2003
© 2003 Oxford University Press

EDITORIAL

Biological Significance of Interventions That Change Breast Density

Rowan T. Chlebowski, Anne McTiernan

Affiliations of authors: R. T. Chlebowski, Harbor-UCLA Research and Education Institute, Torrance, CA; A. McTiernan, Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA.

Correspondence to: Rowan T. Chlebowski, M.D, Ph.D., Harbor-UCLA Research and Education Institute, 1124 W. Carson St., Torrance, CA 90502 (e-mail: rchlebow@whi.org).

The first 10% of the full text of this article appears below.

Mammography provides an image, albeit imperfect, of what isinside the breast. Women with high levels of mammographic density,which reflects the relative proportion of glandular and stromaltissues to fatty tissue in the breast, have been consistentlyshown in observational studies to have a high risk of developingbreast cancer (1–3). In this issue of the Journal, Greendaleand colleagues (4) report the effect of 12 months of postmenopausalhormone therapy on mammographic density among women enrolledin the randomized clinical Postmenopausal Estrogen/ProgestinInterventions (PEPI) Trial, which tested the effects of severalregimens of estrogen plus progestin, estrogen alone as conjugatedequine estrogens, and placebo.

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