© 2002 by Oxford University Press
Journal of the National Cancer Institute, Vol. 94, No. 8, 547-549,
April 17, 2002
© 2002 Oxford University Press
EDITORIAL |
Estrogen, Tamoxifen, and the Brain
Affiliations of authors: P. A. Ganz, University of California at Los Angeles (UCLA) Schools of Medicine and Public Health, and Jonsson Comprehensive Cancer Center at UCLA; S. A. Castellon, Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, and Greater Los Angeles Veterans Administration Health Care System; D. H. S. Silverman, Department of Molecular and Medical Pharmacology, UCLA School of Medicine, and Ahmanson Biological Imaging Center, UCLA.
Correspondence to: Patricia A. Ganz, M.D., Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, 650 Charles Young Dr. South, Los Angeles, CA 900956900 (e-mail: pganz@ucla.edu).
With the aging of the population and the increasing numbers of individuals that are being diagnosed with dementia or milder forms of cognitive dysfunction, there is heightened interest in identifying risk factors and protective factors for this important health problem. A series of recent publications (16) have called increased attention within the cancer community to the complaints of memory loss and decreased cognitive abilities from patients in active chemotherapy treatment, as well as of those who have received chemotherapy within the previous several years. The results of these studies (16) suggest that neurocognitive testing detects clinically significant, but sometimes subtle, abnormalities in a subset of patients who are exposed to both high-dose and standard-dose chemotherapy treatments. In this issue of the Journal, Ernst and colleagues (7) explored the association between the use of tamoxifen therapy in elderly breast cancer patients
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