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JNCI Journal of the National Cancer Institute 2002 94(8):543; doi:10.1093/jnci/94.8.543
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 8, 543, April 17, 2002
© 2002 Oxford University Press

IN THIS ISSUE

COX-2 Inhibitors and Apoptosis in Prostate Cancer Cells

The antitumor activity of cyclooxygenase-2 (COX-2) inhibitors may involve the inhibition of COX-2 enzyme activity and the induction of apoptosis. It is unclear, however, whether COX-2 inhibition is required for apoptosis. Song et al. (p. 585) used tetracycline-inducible COX-2 antisense clones to assess the effect of COX-2 expression on cell viability and sensitivity to apoptosis induced by COX-2 inhibitors. They also performed a structure–activity analysis of celecoxib and various celecoxib derivatives to determine their apoptotic activity on prostate cancer cells. They found that . . . [Full Text of this Article]

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