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JNCI Journal of the National Cancer Institute 2002 94(6):413-414; doi:10.1093/jnci/94.6.413
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 6, 413-414, March 20, 2002
© 2002 Oxford University Press

NEWS

Researchers Explore Role of Gene Transfer in Tumor Growth

Tracy Webb

While studying angiogenesis in Judah Folkman’s laboratory, Lars Holmgren, Ph.D., and his colleagues noticed that, when angiogenesis was blocked, some tumors maintained their size because tumor cells were dying off as quickly as they were proliferating.

"We knew excessive apoptosis takes place, and we wondered, ‘What happens with all that DNA?’" recalled Holmgren, who is now in the Department of Oncology-Pathology at the Karolinska Institute’s Cancer Center in Stockholm, Sweden.

Holmgren set out to determine if neighboring tumor cells can recycle and reuse tumor DNA from cells that have died off through apoptosis. This recycling, called horizontal gene transfer, occurs when genetic material from a donor cell transfers to and propagates in a recipient cell. . . . [Full Text of this Article]

Genetic Diversity

Circulating DNA and Genometastasis

Clinical Implications


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