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JNCI Journal of the National Cancer Institute 2002 94(5):319-321; doi:10.1093/jnci/94.5.319
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 5, 319-321, March 6, 2002
© 2002 Oxford University Press

EDITORIAL

Ras and Seppuku in Neuroblastoma

C. Patrick Reynolds

Correspondence to: C. Patrick Reynolds, M.D., Ph.D., Division of HematologyOncology MS57, Childrens Hospital Los Angeles, 4650 Sunset Blvd., Los Angeles, CA 90027 (e-mail: preynolds@chla.usc.edu).

Neuroblastoma is a malignant tumor of the peripheral nervous system found almost exclusively in young children (1). More commonly than any other malignancy (2), neuroblastoma can undergo complete spontaneous regression without therapy (3–6). Unfortunately, spontaneous regression of neuroblastomas that present clinically is still a rare phenomenon, but it is frequently observed in stage 4-S tumors (infants who present with localized primary tumors and metastases limited to liver, skin, and/or bone marrow) (1,7,8). Intrinsic tumor cell biology is critical in determining spontaneous regression, because stage 4-S tumors rarely have unfavorable biologic features (such as MYCN gene amplification) (8), while infants with MYCN-amplified tumors (most often stage 4) commonly develop relentless progressive disease in spite of chemotherapy (9).

Spontaneous regression . . . [Full Text of this Article]

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