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JNCI Journal of the National Cancer Institute 2002 94(5):317; doi:10.1093/jnci/94.5.317
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 5, 317, March 6, 2002
© 2002 Oxford University Press


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Expression of the Ras Gene and Neuroblastoma Cell Death

Neuroblastoma detected in screening programs frequently undergoes spontaneous regression during its natural course. Kitanaka et al. (p. 358) examined the mechanisms of spontaneous regression of neuroblastoma, focusing on the role of Ras as a favorable prognostic marker. They studied tumors from patients detected through a mass-screening program and from clinically detected, advanced-stage patients older than 1 year of age. They evaluated the tumor tissues for cell degeneration, expression of the Ras gene, and indicators of apoptosis. They found that Ras expression was increased in areas of autophagic . . . [Full Text of this Article]

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