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JNCI Journal of the National Cancer Institute 2002 94(4):239; doi:10.1093/jnci/94.4.239
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 4, 239, February 20, 2002
© 2002 Oxford University Press

IN THIS ISSUE

JC Virus Agno Gene Expression in Human Medulloblastomas

There is growing evidence supporting an association between infection with the JC virus (JCV, a neurotropic polyomavirus) and human brain tumors, including medulloblastomas. Del Valle et al. (p. 267) assessed the presence of JCV Agno gene sequences in a series of 20 well-characterized medulloblastomas. They also determined the expression of agnoprotein and cellular structural and regulatory proteins, including the JCV early gene product, T-antigen. Analysis of amplified DNA from tumor samples revealed the presence of the Agno gene in 69% of samples tested and immunohistochemical cytoplasmic . . . [Full Text of this Article]

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