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JNCI Journal of the National Cancer Institute 2002 94(24):1829-1830; doi:10.1093/jnci/94.24.1829
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 24, 1829-1830, December 18, 2002
© 2002 Oxford University Press

NEWS

RNA-Based Therapy Unlocks Drugs Within Cancer Cells

Jeanne Erdmann

The first 10% of the full text of this article appears below.

RNA provides a potentially versatile target for the detection and treatment of cancer, and scientists are finding creative new ways to use it therapeutically. Nearly one dozen antisense therapies directed against an array of cancers are proceeding through early- to late-phase clinical trials.

John-Stephen Taylor, Ph.D., a chemist at Washington University in St. Louis, Mo., is using RNA as a trigger to set off the catalytic release of chemotherapeutic drugs. He has essentially built a chemical machine that, when it binds to a disease-specific messenger RNA, sparks the release of . . . [Full Text of this Article]


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