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JNCI Journal of the National Cancer Institute 2002 94(23):1740-1742; doi:10.1093/jnci/94.23.1740
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 23, 1740-1742, December 4, 2002
© 2002 Oxford University Press

NEWS

Studies Expand Potential Uses of Photodynamic Therapy

Gail McBride

The first 150 words of the full text of this article appear below.

Photodynamic therapy (PDT) is hardly a mainstream cancer treatment, but new photosensitizers, new light sources and delivery devices, and a plethora of laboratory findings attempting to explain precisely how PDT kills tumor cells are expanding the understanding and use of the therapy.

The concept is relatively simple: Inject into a patient a light-sensitive drug that concentrates primarily in tumor cells, and 2 or 3 days later activate the drug with a light source (usually some kind of laser) directed at the tumor. The drug reacts with the oxygen in the tissue and produces singlet oxygen, which is cytotoxic to tumor cells. For PDT to work, the cancer must be accessible either directly (including in an operative bed) or endoscopically.

Thomas Dougherty, Ph.D., director of the Photodynamic Therapy Center at Roswell Park Cancer Institute (RPCI) in Buffalo, N.Y., first developed photodynamic therapy some 3 decades ago. In addition to many . . . [Full Text of this Article]

Gastrointestinal Cancers

Brain Tumors

Head and Neck Cancer

Bladder Cancers

Intraperitoneal and Pleural Disease


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