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JNCI Journal of the National Cancer Institute 2002 94(22):1662-1663; doi:10.1093/jnci/94.22.1662
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 22, 1662-1663, November 20, 2002
© 2002 Oxford University Press

EDITORIAL

Polymorphic Bacteria Persisting in Polymorphic Hosts: Assessing Helicobacter pylori-Related Risks for Gastric Cancer

Martin J. Blaser

Affiliation of author: Departments of Medicine and Microbiology, New York University School of Medicine, and New York Harbor Veterans Affairs Medical Center, New York, NY.

Correspondence to: Martin J. Blaser, M.D., Department of Medicine, NYU School of Medicine, 550 First Ave., OBV, Rm. 606, New York, NY 10016 (e-mail: martin.blaser@med.nyu.edu).

The first 10% of the full text of this article appears below.

It is becoming increasingly evident that Helicobacter pylori have been normal inhabitants of the human stomach since the earliest times (1) and that, over the course of the twentieth century, H. pylori has been disappearing (2). Because large groups of people can be identified who either do or do not carry the organism, we now can assess the consequences of its presence (and absence). Such studies have shown that the presence of H. pylori is associated with the development of all of the important precursor lesions for adenocarcinoma of the stomach, including chronic gastritis, atrophic gastritis, and intestinal metaplasia and that, in consequence, it is the major risk factor for non-cardia gastric cancers . . . [Full Text of this Article]


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