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JNCI Journal of the National Cancer Institute 2002 94(21):1594-1595; doi:10.1093/jnci/94.21.1594
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 21, 1594-1595, November 6, 2002
© 2002 Oxford University Press


EDITORIAL

Treatment of Nasopharyngeal Cancer: Raising the "Barr"

David Gius, C. Norman Coleman

Affiliation of authors: D. Gius, C. N. Coleman, Radiation Oncology Branch, Center for Cancer Research, Radiation Oncology Sciences Program, National Cancer Institute, Bethesda, MD.

Correspondence to: David Gius, M.D., Ph.D., National Cancer Institute, DCRT, Bldg. 10, Rm. B3B69, MSC 1002, Bethesda, MD 20892–1002 (e-mail: giusd@mail.nih.gov).

The first 10% of the full text of this article appears below.

Nasopharyngeal carcinoma (NPC) is distinguished from other head and neck malignancies by virtue of its unique clinical and pathologic characteristics. NPC is an epithelial tumor with a distinct geographic distribution that is uncommon in Europe and North America but common in southern China (1). Multiple factors play a role in the pathogenesis of NPC, including genetic predisposition, environmental factors, and Epstein-Barr virus (EBV) infection (2–4).

Histopathologically, NPC is separated into the following three categories by the World Health Organization (WHO) (1,5): 1) keratinizing squamous-cell carcinoma similar to other head and neck tumors (type I); 2) nonkeratinizing epidermoid carcinoma (type II); and 3) undifferentiated carcinomas referred to as . . . [Full Text of this Article]


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