© 2002 by Oxford University Press
Journal of the National Cancer Institute, Vol. 94, No. 21, 1594-1595,
November 6, 2002
© 2002 Oxford University Press
EDITORIAL |
Treatment of Nasopharyngeal Cancer: Raising the "Barr"
Affiliation of authors: D. Gius, C. N. Coleman, Radiation Oncology Branch, Center for Cancer Research, Radiation Oncology Sciences Program, National Cancer Institute, Bethesda, MD.
Correspondence to: David Gius, M.D., Ph.D., National Cancer Institute, DCRT, Bldg. 10, Rm. B3B69, MSC 1002, Bethesda, MD 208921002 (e-mail: giusd@mail.nih.gov).
| The first 10% of the full text of this article appears below. |
Nasopharyngeal carcinoma (NPC) is distinguished from other head and neck malignancies by virtue of its unique clinical and pathologic characteristics. NPC is an epithelial tumor with a distinct geographic distribution that is uncommon in Europe and North America but common in southern China (1). Multiple factors play a role in the pathogenesis of NPC, including genetic predisposition, environmental factors, and Epstein-Barr virus (EBV) infection (24).
Histopathologically, NPC is separated into the following three categories by the World Health Organization (WHO) (1,5): 1) keratinizing squamous-cell carcinoma similar to other head and neck tumors (type I); 2) nonkeratinizing epidermoid carcinoma (type II); and 3) undifferentiated carcinomas referred to as