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JNCI Journal of the National Cancer Institute 2002 94(20):1583-1584; doi:10.1093/jnci/94.20.1583
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 20, 1583-1584, October 16, 2002
© 2002 Oxford University Press

CORRESPONDENCE

RESPONSE: Re: Pretest Prediction of BRCA1 or BRCA2 Mutation by Risk Counselors and the Computer Model BRCAPRO

David M. Euhus, Laura Esserman, Patricia A. Ganz, Gordan B. Mills, Gail Tomlinson

Affiliations of authors: D. M. Euhus, G. Tomlinson, The University of Texas Southwestern Medical Center at Dallas; L. Esserman, The University of California, San Francisco; P. A. Ganz, University of California Los Angeles Jonsson Comprehensive Cancer Center, Los Angeles, G. B. Mills, The University of Texas M. D. Anderson Cancer Center, Houston.

Correspondence to: David. M. Euhus, M.D., Division of Surgical Oncology, E6.222, U.T. Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390–9155 (e-mail: david.euhus@UTSouthwestern.edu).

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The data that Bonadona et al. present in their letter illustrates an important aspect of disease probability prediction that cannot be overemphasized: the predictive value of a test (e.g., the BRCAPRO computer model or the subjective estimate of a risk counselor) is related not only to the sensitivity and specificity of the test but also to the prevalence of . . . [Full Text of this Article]


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