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JNCI Journal of the National Cancer Institute 2002 94(20):1582-1583; doi:10.1093/jnci/94.20.1582
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 20, 1582-1583, October 16, 2002
© 2002 Oxford University Press

CORRESPONDENCE

Re: Pretest Prediction of BRCA1 or BRCA2 Mutation by Risk Counselors and the Computer Model BRCAPRO

Valerie Bonadona, Olga M. Sinilnikova, Gilbert M. Lenoir, Christine Lasset

Affiliations of authors: V. Bonadona, C. Lasset, Unit of Prevention and Genetic Epidemiology, Department of Public Health, Cancer Centre Léon Bérard, Lyon, France; O. M. Sinilnikova, Hospices Civils de Lyon and the International Agency for Research on Cancer, Lyon; G. M. Lenoir, Institut Gustave Roussy Villejuif and the International Agency for Research on Cancer, Lyon.

Correspondence to: V. Bonadona, M.D., Unit of Prevention and Genetic Epidemiology, Department of Public Health, Cancer Centre Léon Bérard, 28 rue Laénnec, Lyon 69 008, France (e-mail: bonadona@lyon.fnclcc.fr).

The first 10% of the full text of this article appears below.

Euhus and colleagues (1) have assessed the performance of the computer model BRCAPRO (2) at identifying families likely to carry a deleterious germline mutation in the BRCA1/2 breast/ ovarian cancer predisposing genes in a series of 148 high-risk pedigrees. Compared with subjective assessment by cancer risk counselors, BRCAPRO estimation of BRCA1/2 gene mutation-carrier probabilities showed superior specificity (15.7% versus 31.7%, respectively).

Because the study by . . . [Full Text of this Article]


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