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JNCI Journal of the National Cancer Institute 2002 94(2):77; doi:10.1093/jnci/94.2.77
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 2, 77, January 16, 2002
© 2002 Oxford University Press

IN THIS ISSUE

Cell-Based Assays to Identify Anticancer Agents

Dunstan et al. (p. 88) have developed a cell-based assay to identify anticancer agents that are selectively toxic to cells with defined mutations. They used this assay to identify agents in the National Cancer Institute’s repository of compounds that are selectively toxic to yeast cells deficient in DNA double-strand break repair. They identified and characterized eight agents that are selectively toxic to such yeast cells: two novel topoisomerase II poisons, five agents with topoisomerase I-dependent toxicity, and one agent that bound to DNA and induced strand breaks. They concluded . . . [Full Text of this Article]

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