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JNCI Journal of the National Cancer Institute 2002 94(18):1343; doi:10.1093/jnci/94.18.1343-b
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 18, 1343, September 18, 2002
© 2002 Oxford University Press


IN THIS ISSUE

The first 10% of the full text of this article appears below.

Cancer Incidence in BRCA1 Mutation Carriers

Germline BRCA1 mutations confer a substantial lifetime risk for breast and ovarian cancer, but whether the mutation increases the risk of other cancers is not known. Thompson and Easton (p. 1358) evaluated the risk for cancer at other sites in a large cohort of individuals from families in Europe and North America that carry a BRCA1 mutation. They found that BRCA1 mutation carriers had an increased risk for several cancers, including pancreatic cancer and cancer of the uterine body and cervix. Men with BRCA1 mutations who were younger than 65 years old had an increased risk for prostate cancer but . . . [Full Text of this Article]

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