© 2002 by Oxford University Press
Journal of the National Cancer Institute, Vol. 94, No. 17, 1338-1339,
September 4, 2002
© 2002 Oxford University Press
CORRESPONDENCE |
RESPONSE: Re: 1,1-Dichloro-2,2-bis- (p-chlorophenyl)ethylene and Polychlorinated Biphenyls and Breast Cancer: Combined Analysis of Five U.S. Studies
Affiliations of authors: F. Laden, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; D. J. Hunter, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and Department of Epidemiology and the Center for Cancer Prevention, Harvard School of Public Health, Boston; M. S. Wolff, Division of Environmental and Occupational Medicine, Mount Sinai Medical Center, New York, NY.
Correspondence to: Francine Laden, Sc.D., Channing Laboratory, 181 Longwood Ave., Boston, MA 02115 (e-mail: francine.laden@channing.harvard.edu).
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Glustrom and colleagues question whether residual 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (DDE) and polychlorinated biphenyl (PCB) levels constitute an appropriate biomarker for determining the estrogenic component of organochlorine exposures. They suggest that hydroxylated metabolites of aromatic organochlorines would be more appropriate measures of exposure to estrogenic compounds. Our article and a host of epidemiologic
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