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JNCI Journal of the National Cancer Institute 2002 94(17):1272-1274; doi:10.1093/jnci/94.17.1272
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 17, 1272-1274, September 4, 2002
© 2002 Oxford University Press

NEWS

A One-Two Punch: Light-Based Therapy Finds Tumors, Delivers Treatment

Rabiya S. Tuma

The first 10% of the full text of this article appears below.

Imagine the power of visualizing all of the metastases in a cancer patient and simultaneously targeting each of these lesions with a therapeutic compound. That ideal may not be achievable in the clinic right now, but it is not an outlandish fairy tale either, say experts in the field of molecular imaging. In fact, by combining transcriptional targeting and in vivo imaging, one researcher demonstrated earlier this month that it is already possible in mouse models.


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  		Mice with human prostate cancer tumors were injected with a viral vector that contained a tissue-specific promoter and luciferase. After 3 weeks, images of the mice revealed that luciferase was expressed in the tumor and in the metastases. . . . [Full Text of this Article]

 

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