Skip Navigation

JNCI Journal of the National Cancer Institute 2002 94(17):1270-1272; doi:10.1093/jnci/94.17.1270
© 2002 by Oxford University Press
This Article
Right arrow Full Text Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Friedrich, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Friedrich, M. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of the National Cancer Institute, Vol. 94, No. 17, 1270-1272, September 4, 2002
© 2002 Oxford University Press

NEWS

Despite Checkered Past, Thalidomide and Its Analogues Show Potential

M. J. Friedrich

The first 10% of the full text of this article appears below.

Available in Europe in the late 1950s as a sedative, thalidomide was also used by pregnant women to ameliorate morning sickness. Within a few years, however, its use during pregnancy was linked to severe birth defects in infants, and more than 10,000 children were born with underdeveloped limbs before the drug was withdrawn from the market in 1961.

But thalidomide did not disappear. Not long after its removal from clinical use, it was shown to be effective in treating an inflammatory skin disease that is a complication of leprosy, and in 1998 it was approved for the treatment of this condition.

Curious as to why a drug developed as a sedative had anti-inflammatory effects, researchers were eager to better understand thalidomide’s biologic behavior. Investigations have revealed a broad range of physiologic effects, including immunomodulatory and . . . [Full Text of this Article]

Antiangiogenic Properties

Toxicities and New Analogues

Thalidomide Trials

Possibly More Side Effects


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?