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JNCI Journal of the National Cancer Institute 2002 94(15):1173; doi:10.1093/jnci/94.15.1173
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 15, 1173, August 7, 2002
© 2002 Oxford University Press

CORRESPONDENCE

Re: Effect of Long-Term Estrogen Deprivation on Apoptotic Responses of Breast Cancer Cells to 17{beta}-Estradiol and The Two Faces of Janus: Sex Steroids as Mediators of Both Cell Proliferation and Cell Death

V. Craig Jordan, Hong Liu, Rita Dardes

Affiliations of authors: V. C. Jordan, H. Lui, R. Dardes, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Correspondence to: V. Craig Jordan, OBE, Ph.D., D.Sc., Robert H. Lurie Comprehensive Cancer Center of Northwestern University, 303 E. Chicago Ave., Olson Pavilion Rm. 8258, Chicago, IL 60611 (e-mail: vcjordan@northwestern.edu).

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The recent excellent paper by Song et al. (1) and the accompanying editorial (2) deserve a broader perspective than that presented by the observations with estrogen-deprived MCF-7 cell lines in vitro. Song et al. (1) state that their data on the apoptotic effects of high-dose estrogen could provide insights into the mechanism of pharmacologic estrogen used to treat breast . . . [Full Text of this Article]


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