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JNCI Journal of the National Cancer Institute 2002 94(15):1116-1118; doi:10.1093/jnci/94.15.1116
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 15, 1116-1118, August 7, 2002
© 2002 Oxford University Press

NEWS

The End of an Era? Study Reveals Harms of Hormone Replacement Therapy

Judith Randal

The first 10% of the full text of this article appears below.

A landmark national study has dealt a heavy blow to the decades-old assumption that women with a uterus stand to benefit from hormone replacement therapy (HRT) during and after menopause. Instead, it found that the combination estrogen-progestin regimen used by millions of middle-aged and older women—an estimated 6 million of them in the United States alone—does more harm than good.

The study was funded by a National Institutes of Health program called the Women’s Health Initiative (WHI). Begun in 1993, it is the first study to put HRT through a placebo-controlled randomized clinical trial—the gold standard for the purpose—to examine its risks and benefits in healthy women. Originally scheduled to continue well into 2005, the trial was stopped in early July because, after an average 5.2 years of participant follow-up, 26% more cases of invasive . . . [Full Text of this Article]

Estrogen-Only Therapy

Studies Continue


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