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JNCI Journal of the National Cancer Institute 2002 94(15):1114-1115; doi:10.1093/jnci/94.15.1114
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 15, 1114-1115, August 7, 2002
© 2002 Oxford University Press

EDITORIAL

Is Less More? Lessons in Radiation Schedules in Breast Cancer

Carolyn I. Sartor, Joel E. Tepper

Affiliation of authors: University of North Carolina School of Medicine, Chapel Hill.

Correspondence to: Carolyn I. Sartor, M.D., University of North Carolina School of Medicine, Department of Radiation Oncology, Campus Box 7512, Chapel Hill, NC 27599-7512 (e-mail: sartor@radonc.unc.edu).

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A 1990 National Institutes of Health consensus conference concluded that appropriate conservative therapy for breast cancer includes postexcision breast radiotherapy. However, patterns-of-care studies show that, although more patients are being treated with breast-conserving surgery, the use of radiotherapy in this setting is declining and the likelihood of receiving radiotherapy is related to insurance, race, income, and distance from radiotherapy centers (1–4). To help alleviate the strain on patient and institutional resources that a 5- to 6-week radiotherapy treatment course creates, several Canadian institutions have explored delivery of shorter radiotherapy regimens, demonstrating acceptable cosmesis and local control of breast cancer in prospective nonrandomized and retrospective matched-control series. Although radiobiologic principles dictate . . . [Full Text of this Article]


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