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JNCI Journal of the National Cancer Institute 2002 94(14):1041-1043; doi:10.1093/jnci/94.14.1041
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 14, 1041-1043, July 17, 2002
© 2002 Oxford University Press

EDITORIAL

Adjuvant Chemotherapy for Postmenopausal Lymph Node-Negative Breast Cancer: It Ain't Necessarily So

Antonio C. Wolff, Martin D. Abeloff

Affiliations of authors: A. C. Wolff, Breast Cancer and Drug Development Programs, and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD; M. D. Abeloff, Eli Kennerly Marshall, Jr., Professor and Director, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.

Correspondence to: A. C. Wolff, M.D., The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Bunting-Blaustein Cancer Research Bldg., 1650 Orleans St., Rm. 189, Baltimore, MD 21231–1000 (e-mail: awolff@jhmi.edu).

The first 150 words of the full text of this article appear below.

De t'ings dat yo li'ble
To read in de Bible
It ain't necessarily so . . .
—Ira and George Gershwin, Porgy and Bess (1935)

Adjuvant chemotherapy in older women diagnosed with low-risk, estrogen receptor (ER)-positive breast cancer still inspires controversy. In fact, there is very little information on polychemotherapy in women aged 70 years or older (1), a direct result of our long-standing failure as cancer investigators to recruit older women to clinical trials. In this issue of the Journal, the International Breast Cancer Study Group (IBCSG) presents the results of the IBCSG Trial IX (2). Between 1988 and 1999, 1669 postmenopausal women with lymph node-negative breast cancer were stratified by ER status and randomly assigned to receive either 5 years of tamoxifen alone or three cycles of "classical" CMF (oral cyclophosphamide on days 1–14 plus intravenous methotrexate and 5-fluorouracil on days 1 and . . . [Full Text of this Article]


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