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JNCI Journal of the National Cancer Institute 2002 94(13):1031-1032; doi:10.1093/jnci/94.13.1031
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 13, 1031-1032, July 3, 2002
© 2002 Oxford University Press

CORRESPONDENCE

Re: Blocking Oncogenic Ras Signaling for Cancer Therapy

Silvana Canevari, Silvia Biocca, Mariangela Figini

Affiliations of authors: S. Canevari, M. Figini, Unit of Molecular Therapies, Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy; S. Biocca, Department of Neuroscience, University of Rome "Tor Vergata," Italy.

Correspondence to: S. Canevari, Ph.D., Department of Experimental Oncology, Istituto Nazionale Tumori, 20133 Milan, Italy(e-mail: Canevari@istitutotumori.mi.it).

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We congratulate Adjei (1) on his excellent, comprehensive, and timely review on Ras signaling and the therapeutic implications of blocking this signaling. Perhaps space constraints and a major focus on pharmacologic aspects prevented any discussion of a promising alternative approach to perturbing Ras membrane localization, namely, the diversion of intracellular trafficking by an intracellular antibody (Fig.1Go).


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  		Fig. 1. Intracellular antibody expression . . . [Full Text of this Article]

 

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