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JNCI Journal of the National Cancer Institute 2002 94(11):795-797; doi:10.1093/jnci/94.11.795
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 11, 795-797, June 5, 2002
© 2002 Oxford University Press

NEWS

Movies of Metastasis Shed Light on How Cells Move in the Body

Rabiya S. Tuma

How tumor cells migrate from one site to another in the body is a major question for cancer biologists, but standard metastasis assays look only at the end points of the problem—where the cells start and where they end up.

Now, Peter Friedl, M.D., Ph.D., from the University of Würzburg, Germany, has created a system that allows him to watch tumor cells as they move through the dermis of a live mouse. From these experiments and companion work in vitro, he can see that the cancer cells have a garage full of transportation alternatives and that if one mechanism is blocked, they simply turn to another.


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  		Dr. Peter Friedl

 
In the simplest version of these experiments—using time-lapse confocal microscopy to watch individual tumor cells migrate through a collagen matrix in vitro—Friedl and his colleagues see what . . . [Full Text of this Article]

Role of Metalloproteases

Watching Metastasis in Mice

Mechanism of Migration


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