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JNCI Journal of the National Cancer Institute 2002 94(10):704-705; doi:10.1093/jnci/94.10.704
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 10, 704-705, May 15, 2002
© 2002 Oxford University Press

EDITORIAL

Can ICAM Modulation Prevent Lung Injury From Ionizing Radiation?

Lisa A. Kachnic, Simon N. Powell

Affiliations of authors: L. A. Kachnic, Department of Radiation Oncology, Boston Medical Center, Boston, MA; S. N. Powell, Department of Radiation Oncology, Massachusetts General Hospital, Boston.

Correspondence to: Lisa A. Kachnic, M.D., Department of Radiation Oncology, Boston Medical Center, 88 East Newton St., EB 11, Boston, MA 02118 (e-mail: lisa.kachnic@bmc.org).

Pulmonary fibrosis can develop as a consequence of a multitude of causes, including radiation therapy and chemotherapy, all of which have common physiologic and pathologic responses in the lung. Exposure of normal lung tissue to irradiation has two well-recognized adverse effects: pneumonitis and fibrosis (1). Radiation pneumonitis occurs during the acute injury phase, typically within the first 6 months after treatment. The characteristic histologic finding in patients with radiation pneumonitis is a prominent inflammatory cell infiltrate in the alveoli and in the pulmonary interstitium. Radiation-induced lung fibrosis occurs months to years after irradiation. The pathogenesis of this latter process is less well defined, although . . . [Full Text of this Article]

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