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JNCI Journal of the National Cancer Institute 2001 93(7):488-489; doi:10.1093/jnci/93.7.488
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 7, 488-489, April 4, 2001
© 2001 Oxford University Press

EDITORIAL

Counting Recurrent Events in Cancer Research

Robert J. Glynn, Julie E. Buring

Affiliations of authors: R. J. Glynn, Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, and Department of Biostatistics, Harvard School of Public Health, Boston; J. E. Buring, Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, and Department of Ambulatory Care and Prevention, Harvard Medical School, and Department of Epidemiology, Harvard School of Public Health.

Correspondence to: Robert J. Glynn, Sc.D., Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave., E., Boston, MA 02215–1204 (e-mail: rglynn@rics.bwh.harvard.edu).

In clinical research, outcomes of interest often recur in the same patient. Examples include asthma attacks, urinary-tract infections, migraines, injuries, seizures in epileptics, and admissions to a hospital. Examples in cancer research include recurrent mammary tumors (1), skin cancers (2), and fractures in patients with cancer metastatic to bone (3). However, appropriate statistical methods to compare the occurrence of recurrent events between treatment groups are not widely understood or are they broadly disseminated to the research community. In this issue of the Journal, Cook and Major (4) illustrate the errors that can occur with inappropriate analytic strategies and propose . . . [Full Text of this Article]

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