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JNCI Journal of the National Cancer Institute 2001 93(6):418-419; doi:10.1093/jnci/93.6.418
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 6, 418-419, March 21, 2001
© 2001 Oxford University Press

NEWS

Move Over, Mouse: Make Way for the Woodchucks, Ferrets, and Zebrafish

Cori Vanchieri

The knockout mouse may some day be knocked right off its pedestal. Revered as the best animal model for cancer, the mouse may have to share its glory with such unassuming vertebrates as the woodchuck, the ferret, and zebrafish.

In truth, the mouse has nothing to worry about from its land-based kin. Research with mammals like the woodchuck and ferret is focused on single types of cancer. But the zebrafish may one day swim circles around the overworked mouse. This striped tropical fish appears capable of revealing some of the most fundamental processes involved in cancer.

Plenty of Room at the Top

"I don’t think anyone is worried about other animals supplanting the mouse. The more models the better," said Tom Doetschman, Ph.D., professor of molecular genetics at University of Cincinnati College of Medicine. Doetschman designs knockout mice for a living. "It . . . [Full Text of this Article]

Now You See Them, Now You Don’t

On Dry Land


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