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JNCI Journal of the National Cancer Institute 2001 93(4):261-262; doi:10.1093/jnci/93.4.261
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 4, 261-262, February 21, 2001
© 2001 Oxford University Press

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Snake Venom Protein Paralyzes Cancer Cells

Robert Finn

A component of snake venom has demonstrated its ability to inhibit cancer cell migration in two different cancer models. The protein, called contortrostatin, seems to block cell migration in a novel way.

Francis S. Markland, Ph.D., professor of biochemistry and molecular biology at the University of Southern California Keck School of Medicine, Los Angeles, was examining venom from the southern copperhead Agkistrodon contortrix contortrix for its clot-busting properties when he learned that a group in Taiwan had found disintegrins—integrin antagonists—in the venom of another snake.Go



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