Skip Navigation

JNCI Journal of the National Cancer Institute 2001 93(24):1836-1838; doi:10.1093/jnci/93.24.1836
© 2001 by Oxford University Press
This Article
Right arrow Full Text Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Randal, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Randal, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of the National Cancer Institute, Vol. 93, No. 24, 1836-1838, December 19, 2001
© 2001 Oxford University Press

NEWS

Nanotechnology Getting Off the Ground in Cancer Research

Judith Randal

Researchers at New York’s Memorial Sloan-Kettering Cancer Center have created a novel means to administer radiation therapy by, in effect, cobbling together some off-the-shelf items. Although the only patients on the receiving end of their "nanogenerator" so far have been mice fitted with human cancers (prostate and disseminated lymphoma), the results were the stuff of which oncologists’ dreams are made.

Injections of single atoms of actinium-225 (an alpha-particle emitter) that were individually caged in specially constructed molecules supplied the treatment’s radioactivity. Those molecules were coupled to monoclonal antibodies targeted at the interior of tumor cells. The research team, led by Michael McDevitt, Ph.D., wrote in the Nov. 16 issue of Science that just one single-dose injection "induced tumor regression and prolonged survival, without toxicity, in a substantial fraction of (the) animals." The researchers also reported that the novel technique was effective in . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?