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JNCI Journal of the National Cancer Institute 2001 93(23):1766-1768; doi:10.1093/jnci/93.23.1766
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 23, 1766-1768, December 5, 2001
© 2001 Oxford University Press

NEWS

Beyond the Nobel Prize: Cell Cycle Research Offers New View of Cancer

Ken Garber

This year’s Nobel Prize for physiology or medicine brought welcome recognition to the cell cycle. Awarded to Lee Hartwell, Ph.D., Paul Nurse, Ph.D., and Tim Hunt, Ph.D., for working out cell cycle regulation, the prize gave official stamp to the revolution that has transformed this once-shunned area of research over the last 30 years. The implications for cancer research and treatment are far-reaching.


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  		Dr. Lee Hartwell

 

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  		Paul Nurse, Ph.D., (left) and Tim Hunt, Ph.D., of the Imperial Cancer Research Fund, London.

 
In 1970, the cell cycle was a black box. Scientists, through microscopes, had long observed the exquisitely choreographed sequence of events culminating in mitosis: Cells grew, replicated their DNA, segregated their chromosomes into two identical sets, and divided. But which molecules drove cell division, and which abnormalities set off uncontrolled cell division and cancer, remained completely unknown—to the extent that few scientists were willing to tackle the . . . [Full Text of this Article]


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