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JNCI Journal of the National Cancer Institute 2001 93(23):1764-1765; doi:10.1093/jnci/93.23.1764
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 23, 1764-1765, December 5, 2001
© 2001 Oxford University Press


EDITORIAL

Hormone Replacement Therapy and Adenoma Recurrence: Implications for Its Role in Colorectal Cancer Risk

María Elena Martínez

Correspondence to: María Elena Martínez, Ph.D., Arizona Cancer Center and College of Public Health, University of Arizona, 1515 N. Campbell Ave., Tucson, AZ 85724 (e-mail: emartinez@azcc.arizona.edu).

In this issue of the Journal, Woodson et al. (1) present findings on the role of hormone replacement therapy (HRT) and the risk of adenoma recurrence from a prospective study nested in the Polyp Prevention Trial (PPT). Their results show that current HRT use is not associated with recurrence of adenomatous polyps. However, the investigators did observe a statistically significant interaction by age. Among women aged 62 years and older, an inverse association between HRT use and the risk of adenoma recurrence was shown (odds ratio [OR] = 0.58; 95% confidence interval [CI] = 0.35 to 0.97), whereas among women aged . . . [Full Text of this Article]

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