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JNCI Journal of the National Cancer Institute 2001 93(22):1673-1675; doi:10.1093/jnci/93.22.1673
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 22, 1673-1675, November 21, 2001
© 2001 Oxford University Press

EDITORIAL

The Two Faces of Janus: Sex Steroids as Mediators of Both Cell Proliferation and Cell Death

Ana M. Soto, Carlos Sonnenschein

Affiliation of authors: Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA.

Correspondence to: Ana M. Soto, M.D., Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111 (e-mail: ana.soto@tufts.edu).

In this issue of the Journal, Song et al. (1) report that prolonged estrogen withdrawal in breast cancer cells results in the acquisition of an apoptotic response to 17{beta}-estradiol; i.e., the very same hormone that mediates the proliferation of its target cells in the female genital tract and mammary glands is also able to trigger their death. In this editorial, we aim to integrate these experimental results, which are obviously relevant to the management of breast cancer, within a biologic perspective.

The exploration of nature never ceases to surprise biologists. When adopting a narrow anthropocentric approach, we imagine nature as designed by a meticulous engineer. However, a more appropriate metaphor would be to imagine instead the workings of nature as the fruit of tinkering, or putting old devices to new uses. From this evolutionary perspective, it is conceivable that the same sex steroid hormones mediate the increase . . . [Full Text of this Article]

INDUCTION OF CELL PROLIFERATION

INHIBITION OF CELL PROLIFERATION

INDUCTION OF CELL DEATH

ESTROGEN-INDUCED CELL DEATH IN TREATMENT OF BREAST CANCER

REFERENCES


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