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JNCI Journal of the National Cancer Institute 2001 93(2):92-94; doi:10.1093/jnci/93.2.92
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 2, 92-94, January 17, 2001
© 2001 Oxford University Press

NEWS

When Theories Collide: Experts Develop Different Models for Carcinogenesis

Tracy Webb

The current dogma of cancer research is that the accumulation of gene mutations in a single cell is responsible for the development and progression of human cancers. "Almost everybody believes that cancer requires certain gene mutations," noted Christoph Lengauer, Ph.D., associate professor of oncology at Johns Hopkins University, Baltimore. "Several genes have to be affected in order to generate cancer, and genetic instability [caused by gene mutations] allows for the accumulation of [these] mistakes."

But this theory is open to debate. Robert Weinberg, Ph.D., professor of cancer research at the Massachusetts Institute of Technology, Cambridge, agrees with Lengauer and believes that tumor cells arise from disruptions in critical signaling pathways as a result of mutations in various oncogenes and tumor . . . [Full Text of this Article]

Aneuploidy and Oncogenesis

One of Many Changes?

Exclusive Theories or Cooperation?


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