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JNCI Journal of the National Cancer Institute 2001 93(2):88-89; doi:10.1093/jnci/93.2.88
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 2, 88-89, January 17, 2001
© 2001 Oxford University Press

NEWS

LIM Kinase Appears Critical in Metastasis, But How?

Robert Finn

Two papers presented at the same poster session of the 40th annual meeting of the American Society for Cell Biology separately concluded that an enzyme named LIM kinase is apparently critical in cell motility and perhaps the process of metastasis. The only problem is that the papers come to opposite conclusions about the enzyme’s effects and suggest opposite strategies for cancer therapy.

The studies conclude that LIM kinase either promotes motility and should be inhibited to arrest metastasis, or the enzyme itself inhibits motility . . . [Full Text of this Article]


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