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JNCI Journal of the National Cancer Institute 2001 93(18):1370-1371; doi:10.1093/jnci/93.18.1370
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 18, 1370-1371, September 19, 2001
© 2001 Oxford University Press

NEWS

Platypus Study Answers Questions About Gene Imprinting

F. B. Dunn

Can a platypus get cancer? It was a moot question until recent research revealed that the oddball egg-layer shares a propitious trait with people. This genetic feature lowers the risk for cancer, challenges the notion that mice make the best cancer models, and may even have implications in human cloning.

It all began when radiation oncologist Randy Jirtle, Ph.D., of Duke University Medical Center, Durham, N.C., became interested in a gene for the receptor of insulin-like growth factor-II (IGF2R; also called M6P/IGF2R because the receptor binds the protein mannose-6-phosphate as well). Jirtle and his team identified IGF2R, important in prenatal and postnatal growth and development, . . . [Full Text of this Article]


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