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JNCI Journal of the National Cancer Institute 2001 93(18):1364-1365; doi:10.1093/jnci/93.18.1364
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 18, 1364-1365, September 19, 2001
© 2001 Oxford University Press

EDITORIAL

Collapsin Response Mediator Protein-1: a Lung Cancer Invasion Suppressor Gene With Nerve

Patricia S. Steeg

Affiliation of author: Women's Cancers Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD.

Correspondence to: Patricia S. Steeg, Ph.D., National Institutes of Health, Bldg. 10, Rm. 2A33, Bethesda, MD 20892 (e-mail: steeg@helix.nih.gov).

The metastasis field welcomes a new member, collapsin response mediator protein-1 (CRMP-1), which is reported to be a lung cancer invasion suppressor gene by Shih et al. (1) in this issue of the Journal. Shih et al. examined differential gene expression among a panel of lung carcinoma cell lines of varying invasive abilities by use of a 9600 complementary DNA microarray analysis. They wisely concentrated on the expression and function of one gene, CRMP-1. The less invasive lung cancer cell lines expressed relatively high levels of CRMP-1 messenger RNA (mRNA) and protein. Transfection of CRMP-1 into the highly invasive CL1–5 cell line reduced invasion through a Matrigel-coated membrane by approximately half. What makes this in vitro cell line observation intriguing is the . . . [Full Text of this Article]

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