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JNCI Journal of the National Cancer Institute 2001 93(18):1363; doi:10.1093/jnci/93.18.1363
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 18, 1363, September 19, 2001
© 2001 Oxford University Press

IN THIS ISSUE

CRMP-1 Gene and Invasion and Metastasis of Cancer Cells

Studies of differential gene expression in metastatic cells with high versus low invasive activity may help identify genes associated with metastasis. Shih et al. (p. 1392) used microarray technology to select CRMP-1, a gene whose expression is inversely associated with the invasive activity of cancer cells. They found that, when the CRMP-1 gene was transfected into highly invasive cells and then overexpressed, transfected cells had lower invasive activity than untransfected cells. CRMP-1 protein was distributed uniformly in the cytoplasm in interphase cells, but in mitotic cells, CRMP-1 was associated with mitotic spindles . . . [Full Text of this Article]

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