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JNCI Journal of the National Cancer Institute 2001 93(17):1287-1288; doi:10.1093/jnci/93.17.1287
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 17, 1287-1288, September 5, 2001
© 2001 Oxford University Press


NEWS

Recent Studies Bring Risks, Benefits of Hormone Replacement Therapy Under Scrutiny

M.J. Friedrich

Over the years, estrogen replacement therapy has promised not only to spare a woman from menopausal symptoms but also to lower her risk for cardiovascular disease and osteoporosis and even possibly prevent the onset of Alzheimer’s disease and colon cancer.

Under close scrutiny, estrogen presents a more complex picture. Estrogen does alleviate menopausal symptoms and increase bone mineral density; however, it also increases the risk of endometrial cancer. To counteract this danger, progesterone—in the form of progestins—have been added to estrogen in the hormone replacement therapy mix.

But recent studies suggest that a woman’s breast cancer risk, which is slightly elevated when she is taking ERT, increases further when estrogen is coupled with progestins. Other trials raise questions about estrogen’s . . . [Full Text of this Article]

Observational Studies

Cardiovascular Concerns

‘Not Living Up to Their Promise’

Medical Alternatives


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