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JNCI Journal of the National Cancer Institute 2001 93(17):1284-1286; doi:10.1093/jnci/93.17.1284
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 17, 1284-1286, September 5, 2001
© 2001 Oxford University Press

NEWS

Debate on the Link Between SV40 and Human Cancer Continues

Nancy J. Nelson

Emotions run high on the topic of the monkey virus SV40 and its relationship to human cancer.

Some scientists believe that the virus likely plays a role in development of some human cancers, while others are skeptical. And underlying these divisions are more fundamental disagreements about whether SV40 even infects humans and whether laboratory tests can discriminate between an infection by SV40 and those by similar viruses.

The discovery of SV40 in the earliest polio vaccines in the 1950s set off several decades of research, most of which was reassuring. While SV40 causes cancer in hamsters and abnormalities in human cells, 40 years of epidemiological studies in hundreds of millions of people have found no evidence that those exposed to the virus have an increased risk of cancer (see sidebar, p. 1286).

However, controversy came into the picture in 1990s with the advent of the polymerase chain reaction, an . . . [Full Text of this Article]

The Skeptics

Almost Believers and Believers

Is Human Infection Possible?

Proving Presence of SV40


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