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JNCI Journal of the National Cancer Institute 2001 93(17):1282-1283; doi:10.1093/jnci/93.17.1282
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 17, 1282-1283, September 5, 2001
© 2001 Oxford University Press

EDITORIAL

Origin of Colorectal Cancers in Hyperplastic Polyps and Serrated Adenomas: Another Truism Bites the Dust

Stanley R. Hamilton

Correspondence to: Stanley R. Hamilton, M.D., Division of Pathology and Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 85, Houston, TX 77030 (e-mail: shamilto@mdanderson.org).

Colorectal carcinoma is the second most common cause of cancer deaths in the United States (1), and on average approximately six people die every hour of every day as a result of this malignancy. Because these tumors are so frequent and so obvious on the mucosal surface of the large bowel, their morphogenesis has attracted great attention over the centuries (2). The evolution of understanding of the pathogenesis of colorectal cancer in recent years is nothing short of remarkable, especially during the era of molecular pathology. The article by Hawkins and Ward (3) in this issue of the Journal contributes to that evolution.

After considerable debate in the medical literature about the existence of de novo cancer and the classification of colorectal polyps . . . [Full Text of this Article]

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