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JNCI Journal of the National Cancer Institute 2001 93(16):1200-1202; doi:10.1093/jnci/93.16.1200
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 16, 1200-1202, August 15, 2001
© 2001 Oxford University Press

NEWS

BRCA1: Lessons Learned From The Breast Cancer Gene

Tom Reynolds

A decade ago, the hunt for the elusive breast cancer gene was in full swing. Scientists predicted that its imminent discovery would shed light on the origins of breast cancer not only for women who inherit a mutant gene, but for the thousands more who are diagnosed each year with noninherited forms of breast cancer.

GoMary-Claire King, Ph.D., was then at the University of California at Berkeley, performing family studies that narrowed the search to a small region on chromosome 17. BRCA1 was finally cloned in 1994 by a group led by University of Utah scientists and was followed the next year by a second susceptibility gene, BRCA2. But after years of intense scrutiny, these genes have produced little insight into the workings of breast cancer—or for that matter, ovarian cancer, also associated with BRCA1. Instead, they have raised . . . [Full Text of this Article]


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