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JNCI Journal of the National Cancer Institute 2001 93(16):1188-1189; doi:10.1093/jnci/93.16.1188
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 16, 1188-1189, August 15, 2001
© 2001 Oxford University Press

EDITORIAL

Role of Population-Based Studies in Assessing Genetic Cancer Risk

Donald A. Berry

Correspondence to: Donald A. Berry, Ph.D., Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 447, Houston TX 77030–4009 (e-mail: dberry@odin.mdacc.tmc.edu).

The article by Loman et al. (1) in this issue of the Journal reports rates of germline mutations of breast and ovarian cancer susceptibility genes BRCA1 and BRCA2 among Swedish women who were diagnosed with breast cancer at age 40 years or less. The study is population based and includes all breast cancer patients diagnosed in southern Sweden during the period from 1990 through 1995. The study's principal conclusion is that 9% (21 of 234) of these young patients carried mutations. Among the youngest women, those younger than 36 years, the rate was 16% (13 of 81), whereas the corresponding rate for women aged 36–40 years was 5% (eight of 153). Not surprisingly, women with a family history of breast or ovarian cancer (which was about half of the women in the study) were at greater risk of testing positive for carrying a mutation.

These estimates are similar . . . [Full Text of this Article]

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