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JNCI Journal of the National Cancer Institute 2001 93(16):1187; doi:10.1093/jnci/93.16.1187
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 16, 1187, August 15, 2001
© 2001 Oxford University Press


IN THIS ISSUE

Population-Based Estimates of Breast Cancer Gene Mutations

BRCA1 and BRCA2 are the major genes involved in inherited susceptibility to breast cancer. Most studies published to date are based on selected groups of patients and their families recruited from high-risk referral clinics, which makes it difficult to evaluate the role that mutations in these genes play in the general population. Loman et al. (p. 1215) studied BRCA1 and BRCA2 mutations in women diagnosed with breast cancer before the age of 41 years in southern Sweden from 1990 through 1995, along with the history of breast and ovarian cancers . . . [Full Text of this Article]

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